Scientists have uncovered changes in neurological structure that could underlie the autism spectrum disorder known as Pitt Hopkins syndrome, thanks to the help of lab-grown brains developed from human cells.
spectrum on account of its severe impact on motor skills and sensory integration, it's a complex condition that presents with a range of severities.
By studying the progress of tissues with the mutated versions of TCF4 taken from individuals with Pitt Hopkins syndrome, and comparing them against tissues with more typical TCF4 genes, the researchers could map changes in the tissues' structure and operation.pediatrician Alysson R. Muotri from UC San Diego.
Part of the cause of this drop in neural differentiation seems to be a drop in a specific type of signaling that occurs across cell membranes. "The fact that we can correct this one gene and the entire neural system reestablishes itself, even at a functional level, is amazing,"It's a small key piece of information that could one day lead to some revolutionary therapies, though that day is still a long way off.
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