A new 'Large Particle Detection' (LPD) mode has been introduced to SR-DLS instruments, enabling rapid identification and characterization of oversized particles in nanosuspensions. This advancement complements existing in/on/at-line size analysis capabilities, providing a comprehensive solution for non-invasive monitoring of particle size distribution.
Particle size characterization in nanosuspensions often focuses on ‘majority’ features of the size distribution. Yet, for various suspensions in (bio)pharmaceuticals or fine chemicals, small fractions of ‘oversized’ particles can significantly impact their quality and safety. Efficient characterization of these particles -especially during suspension processing- remains a challenge.
Here, a new mode is introduced to the established in/on/at-line size characterization capabilities of SR-DLS instruments (NanoFlowSizer): ‘Large Particle Detection’ (LPD). It provides rapid information of ‘rare’ aggregates and oversizers using high-speed cross-sectional video-imaging. The combined information from SR-DLS and LPD significantly extends current non-invasive measurement capabilities for nanosuspensions
NANOPARTICLES SUSPENSIONS SR-DLS LARGE PARTICLE DETECTION CHARACTERIZATION
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