Study highlights the significant impact of genetic risk and lifestyle on early- and late-onset cardiovascular diseases, showing that lifestyle improvements can notably reduce CVD risk, especially in high genetic risk individuals.
By Priyanjana Pramanik, MSc.Reviewed by Susha Cheriyedath, M.Sc.Jul 14 2024 A recent study published in the journal Nature Human Behavior explored the interactions between genetic risk and lifestyle factors on the onset and types of cardiovascular disease .
Polygenic risk scores calculated using genome-wide association studies can help predict an individual's genetic predisposition to diseases like coronary artery disease , especially in European populations. Related StoriesThe study involved participants from the China Kadoorie Biobank, an ongoing prospective cohort study that enrolled over half a million adults aged 30 to 79 from urban and rural areas in China.
Genetic risk scores were created using data from other studies and statistical models. Participants were classified into low, intermediate, and high genetic risk groups. Various statistical methods were employed to assess the relationship between genetic risk, lifestyle factors, and the onset of CVDs. Sensitivity analyses were conducted to ensure the robustness of the findings.
Heart Heart Disease Cardiovascular Disease Coronary Artery Disease Genome Intracerebral Hemorrhage Ischemic Stroke Research Stroke
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