Red blood cells are the most abundant cells in the body. It has long been known that when red blood cells break down or anemia occurs due to bleeding, the hormone erythropoietin (EPO) increases, leading to the proliferation of immature cells (erythroblasts) that eventually become red blood cells, thus restoring the red blood cell count.
Kumamoto UniversitySep 20 2024 Red blood cells are the most abundant cells in the body. It has long been known that when red blood cells break down or anemia occurs due to bleeding, the hormone erythropoietin increases, leading to the proliferation of immature cells that eventually become red blood cells , thus restoring the red blood cell count. However, how more primitive "hematopoietic stem cells " respond to severe anemia has been largely unclear.
It was discovered that after acute anemia was induced, hematopoietic stem cells began to proliferate immediately. Moreover, the hematopoietic stem cells of anemic mice produced more red blood cells compared to other blood cells, a response not seen in normal mice. Since hematopoietic stem cells do not respond to erythropoietin, the researchers conducted genetic analysis to identify what triggers the changes in these cells.
Cell Cell Production Research Anemia Apolipoprotein Bleeding Bone Bone Marrow Erythropoietin Genes Genetic Hormone Lipoprotein Metabolism Platelets Receptor Red Blood Cells Stem Cells
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