This review highlights the potential of lipidomic and metabolomic biomarkers in predicting breast cancer prognosis and therapy response, enhancing patient care.
By Pooja Toshniwal PahariaReviewed by Danielle Ellis, B.Sc.Sep 5 2024 Review provides overview of the current translational potential of metabolic and lipidomic biomarkers for predicting breast cancer prognosis and response to therapy. A recent review in npj Metabolic Health and Disease discusses the potential of lipidomic and metabolic biomarkers to predict breast cancer prognosis and treatment response.
They may facilitate early detection, monitoring, and personalized treatments. This would improve therapy results, reduce overtreatment, and increase patient quality of life. Cancer cells need glucose uptake and metabolic activity to grow and proliferate. Tumors alter nutrient consumption, with redox imbalance being a hallmark. Metabolomics enables the development of medications that target glucose transporters, such as phloretin and WZB117, as well as crucial glycolytic enzymes. Breast cancer cells use antioxidant mechanisms to maintain redox equilibrium and survival.
Lipidomic markers of progressive breast cancer Cancer cells need lipids like sterols, phospholipids, and glycerides for cell membrane formation, cell signaling, and energy storage. Breast cancer progression boosts lipogenesis and alters lipids to meet the higher metabolic needs and enable the rapid growth of tumor cells. Cancer cells use lipolysis and beta-oxidation to break down stored fatty acids and triglycerides for swift cellular division and invasion.
Myeloid cells lower immune responses in cancer. The types of myeloid cells involved are eosinophils, polymorphonuclear neutrophils, macrophages, dendritic cells, basophils, and megakaryocytes. TAMs enable the reprogramming of cells to pro-tumorigenic states. Lipids also help form blood vessels that supply nutrients to cancer cells.
Cancer Lipidomics Metabolomics Bile Cell Cholesterol Glucose Lipids Lymph Nodes Mammography Metabolism Metabolites Metastasis Proline Taurine Tumor
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