This research highlights the indirect role of fructose in cancer, revealing how liver metabolism enhances tumor growth through lipid-mediated mechanisms.
By Dr. Chinta SidharthanReviewed by Danielle Ellis, B.Sc.Dec 5 2024 Research uncovers how cancer cells exploit fructose as an alternative fuel for growth, revealing a surprising metabolic process
Background Cancer cells are known to use glucose extensively for energy and growth in a phenomenon termed the Warburg effect. Recent research has highlighted the potential role of fructose in tumor growth. Fructose is a naturally occurring sugar that is metabolized differently from glucose and is processed primarily by the liver.
The researchers also conducted in vitro experiments where cancer cell lines were cultured with labeled fructose to assess their ability to metabolize the sugar. Additionally, co-culture experiments were also performed where cancer cells were paired with liver cells to evaluate the role of hepatic metabolism in supporting tumor growth.
The study also included comparative assessments of the metabolic pathways of glucose and fructose to highlight the distinct but indirect role of fructose in tumor growth. Overall, the study combined genetic, biochemical, and dietary interventions to detect how the liver converts fructose into metabolites that indirectly fuel tumor growth while providing a comprehensive understanding of inter-organ metabolic interactions.
Furthermore, the inhibition of KHK-C reduced the circulating LPC levels and significantly impeded tumor growth, confirming that the enzyme plays an important role in fructose metabolism and nutrient transfer.
Fructose Lipids Liver Proliferation Tumor Cell Cell Proliferation Enzyme Glucose Metabolism Metabolites Research
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