Liver X receptor beta (LXRβ) shows potential in reducing depression and anxiety by improving neurogenesis, reducing neuroinflammation, and enhancing cognitive and emotional function. More research on LXR agonists could reveal new treatments for mental health disorders.
By Pooja Toshniwal PahariaReviewed by Benedette Cuffari, M.Sc.Oct 8 2024 New research highlights how activating LXRβ can restore brain function and improve symptoms of anxiety and depression, suggesting novel therapeutic strategies for mental health treatment.
LXRβ protects fetal neurons in the peripheral and central nervous systems. In the central nervous systems of adults, LXRβ can be found in various cell types, some of which include microglia, astrocytes, and oligodendrocytes. GW3965 improves hippocampal neurogenesis, thereby preventing microglial activity and reducing neuronal inflammation. Moreover, GW3965 encourages oligodendrocyte development and myelination, both of which enhance cognitive and emotional processes to ultimately ameliorate depression-like behaviors.
Anxiety and depression are often present in individuals with autism spectrum disorders and schizophrenia. Animals lacking LXRβ exhibit early changes in neurogenesis that lead to autistic-like behaviors.
Depression Liver Receptor Agonist Antidepressant Brain Cell Children Cholesterol Chronic Cortex Enzyme Hippocampus Inflammation Ligand Medicine Mental Disorder Metabolism Microglia Neurogenesis Neurons Schizophrenia Stress Transcription Transcription Factors
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