Long-acting injectable cabotegravir (CAB-LA) was safe and well tolerated as HIV pre-exposure prophylaxis (PrEP) before and during pregnancy in the follow-up phase of a global study among cisgender women.
NIH/National Institute of Allergy and Infectious Diseases Jul 23 2024 Long-acting injectable cabotegravir was safe and well tolerated as HIV pre-exposure prophylaxis before and during pregnancy in the follow-up phase of a global study among cisgender women. The analysis of outcomes from more than 300 pregnancies and infants will be presented at the 2024 International AIDS Conference in Munich, Germany.
Jeanne Marrazzo, M.D., M.P.H., Director of the National Institutes of Health's National Institute of Allergy and Infectious Diseases There were 367 pregnancies in this phase of the study. Pregnancy-related maternal adverse event incidence was 45.7, 47.1, and 37.5 per 100 person years among people using CAB-LA during pregnancy, prior to pregnancy, or with no CAB-LA use, respectively. Adverse infant outcomes were similar across groups, with negative outcomes reported in 33%, 38%, and 27% of pregnancies with CAB-LA use, prior CAB-LA use, or no CAB-LA use, respectively.
Pregnancy AIDS Allergy Cell Electron Healthcare HIV-1 Infectious Diseases Medical Research Membrane Micrograph Pre-Exposure Prophylaxis Prophylaxis Research Virus
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