Long COVID brain fog and fatigue negatively impact all facets of daily life Brain LongCOVID PASC Neurology BrainFog Fatigue Coronavirus Disease COVID IJERPH_MDPI uiowa VAIowaCity
Study: Brain Fog and Fatigue following COVID-19 Infection: An Exploratory Study of Patient Experiences of Long COVID. Image Credit: DOERS / Shutterstock
About the study In the present study, the researchers recruited adult participants who had long-lasting health complications three months after recovering from SARS-CoV-2 infections. The participants were patients at the Post-COVID-19 Clinic, a part of the University of Iowa Hospitals and Clinics. Results The results suggested that brain fog and fatigue impacted all aspects of the patient's life, including daily activities, interpersonal relationships, and employment. Patients reported difficulty completing household chores, personal tasks such as exercise, and leisure activities such as reading and gardening. These difficulties made the regular running of the household more challenging.
While 40% of the participants were unemployed due to PASC symptoms, the employed participants reported that the employers were accommodative and emotionally supportive. However, the impact of PASC symptoms on the ability to work changed their self-perceptions about capabilities and skills. The decreased ability to multi-task made them feel less productive and efficient at their jobs.
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Prednisolone does not improve olfactory function after COVID-19: a randomized, double-blind, placebo-controlled trial - BMC MedicineBackground Prednisolone has been suggested as a treatment for olfactory disorders after COVID-19, but evidence is scarce. Hence, we aimed to determine the efficacy of a short oral prednisolone treatment on patients with persistent olfactory disorders after COVID-19. Methods We performed a randomized, double-blind, placebo-controlled, single-centered trial in the Netherlands. Patients were included if they were | 18 years old and if they had persistent (| 4 weeks) olfactory disorders within 12 weeks after a confirmed COVID-19 test. The treatment group received oral prednisolone 40 mg once daily for 10 days and the placebo group received matching placebo. In addition, all patients performed olfactory training. The primary outcome was the objective olfactory function on Sniffin’ Sticks Test (SST) 12 weeks after the start of treatment, measured in Threshold-Discrimination-Identification (TDI) score. Secondary outcomes were objective gustatory function assessed by the Taste Strip Test (TST) and subjective self-reported outcomes on questionnaires about olfactory, gustatory and trigeminal function, quality of life, and nasal symptoms. The CONSORT 2010 guideline was performed. Results Between November 2021 and February 2022, we included 115 eligible patients, randomly assigned to the treatment (n = 58) or placebo group (n = 57). No difference in olfactory function between groups was obtained after 12 weeks. Median TDI score on SST was 26.8 (IQR 23.6–29.3) in the placebo group and 28.8 (IQR 24.0–30.9) in the prednisolone group, with a median difference of 2.0 (95% CI 0.75 to 1.5). There was similar improvement on olfactory function in both groups after 12 weeks. Furthermore, on secondary outcomes, we obtained no differences between groups. Conclusions This trial shows that prednisolone does not improve olfactory function after COVID-19. Therefore, we recommend not prescribing prednisolone for patients with persistent olfactory disorders after COVID-19. Trial registration Thi
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