Researchers designed a cross-sectional study to investigate the biological underpinnings of “Long COVID”, the post-acute infection syndrome triggered by SARS-CoV-2.
By Neha MathurSep 27 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in Nature, researchers designed a cross-sectional study to investigate the biological underpinnings of “Long COVID” , the post-acute infection syndrome triggered by severe acute respiratory syndrome coronavirus 2 .
LC presents a constellation of debilitating symptoms, such as fatigue and cognitive deficits; additionally, its prevalence is high. Some prospective studies have suggested that one in eight people with COVID-19 experience persistent symptoms, likely because viral remnants in tissues activate autoimmunity or cause microbial dysbiosis. In some cases, chronic inflammation causes tissue damage.
They used multi-dimensional immunophenotyping and unbiased machine learning to identify potential LC biomarkers in data aggregated from all five cohorts. The study follow-up lasted over 12 months. Conversely, autoantibodies to human exoproteome did not significantly differ between LC and controls. Thus, whether autoreactive T cells play a role in LC pathogenesis requires future investigation.
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