This study explores the association between self-assessed appetite and mortality in patients suffering from advanced cancer. Secondary aims include the relation between fatigue, albumin levels, and CRP/albumin ratio and mortality. The study also investigates potential sex differences in these associations.
Loss of appetite is a common nutrition symptom in patients with cancer. Understanding the trajectory of appetite could be of clinical use for prognostication in palliative cancer care. Our primary aim was to explore the association between self-assessed appetite and mortality in patients suffering from advanced cancer . Secondary aims included the relation between fatigue, albumin levels and CRP/albumin ratio and mortality. We also aimed to study potential sex-differences in the associations.
Post-hoc analyses were performed using data from the Palliative D-study comprising 530 patients with cancer admitted to palliative care. Appetite and fatigue were assessed with the Edmonton Symptom Assessment System (ESAS). Cox proportional hazards models were used to calculate Hazard ratios (HR) with 95% confidence intervals (CI) for exposures of appetite, fatigue, albumin and CRP/albumin ratio, and time from study inclusion to death or censoring. Analyses were also performed stratified by sex.The follow-up time ranged between 7 to 1420 day
Loss Of Appetite Nutrition Symptom Cancer Patients Mortality Advanced Cancer Fatigue Albumin Levels CRP/Albumin Ratio Sex Differences
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