This study shows a carbohydrate-restricted diet boosts β-cell function in type 2 diabetes, offering a sustainable approach to manage the disease effectively.
By Vijay Kumar MalesuReviewed by Danielle Ellis, B.Sc.Oct 24 2024 Following a low-carb diet may potentially help patients manage disease more effectively and reduce medication use.
Background β-Cell failure and insulin resistance contribute to the onset and progression of T2D, with a decline in first-phase insulin secretion playing a critical role in glucose management. Inadequate first-phase response leads to elevated glucose and insulin levels, causing complications like glycosylation and lipid abnormalities. Existing T2D medications do not enhance first-phase secretion, and treatment costs are high.
About the study Participants in the present study included African American and European American adults with T2D, identified through self-reported race. Inclusion criteria comprised a T2D diagnosis within the past decade, treatment with dietary changes or specific medications, and being aged 35 to 65 years, with a glycated hemoglobin A1c of 8.0 or lower and a body mass index between 25 and 50. Participants with glucocorticoid use, significant weight changes, or substance abuse were excluded.
Study results A total of 65 participants were enrolled in the study, which included AA and EA adults diagnosed with T2D. Eight participants withdrew themselves from the study for various reasons like personal issues, nonadherence to the diet, and a coronavirus disease 2019 shutdown. Ultimately, 57 participants completed the 12-week diet intervention, successfully finishing both the baseline OGTT and hyperglycemic clamp, while some participants contributed data from only one of the tests.
Diabetes Diet Type 2 Diabetes Blood Blood Sugar Carbohydrate Chronic Endocrinology Glucose Glycosylation High Blood Sugar Insulin Insulin Resistance Metabolism Research Surgery
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