The vast majority of young patients given a low-dose boost of radiotherapy to the site where their breast cancer was removed in addition to whole breast radiotherapy, remained free of local recurrence after ten years, according to results of the 'Young boost trial' presented at the 14th European Breast Cancer Conference.
Low-dose radiotherapy boost helps prevent local recurrence with better cosmetic outcomes in young breast cancer patientsThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by Tom Misteli, Ph.D., and Karen Meaburn, Ph.D. at the NIH IRP.
Patients treated with a high-dose boost had an even lower risk of recurrence; however, they were much more likely to develop scar tissue in the breast, resulting in hardening of the breast. The trial included 2,421 patients who were all aged 50 or younger, with an average age of around 45, and being treated at one of 32 centers in The Netherlands, France, or Germany. Following surgery to remove their tumors and whole breast radiotherapy, the patients were randomly assigned to be treated with either the low-dose or high-dose radiotherapy boost. The majority of patients also received chemotherapy.
Dr. Bosma said,"In both groups local recurrence rates were very low and much better than expected. Although we did find a difference between the two groups in terms of the recurrence rate, this was a small difference which must be weighed against the increase in side effects, such as fibrosis. Knowing the long-term impact of a treatment on cancer control as well as on unwanted side-effects is crucial in helping individual patients get the best possible treatment.
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