A meta-analysis found that low serum vitamin D levels significantly increase the risk of developing type 2 diabetes in older adults, even after adjusting for several confounders.
By Dr. Sushama R. Chaphalkar, PhD.May 27 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent systematic review and meta-analysis published in the journal Nutrients , researchers from Italy updated a systematic review and meta-analysis to examine whether low serum vitamin D levels can predict the onset of type 2 diabetes in older adults. Despite adjusting for several confounders, they found that low 25OHD levels were associated with an increased risk of developing T2D in older adults.
Vitamin D deficiency, common in older adults, is associated with an increased risk of T2D, potentially due to its role in pancreatic insulin secretion, metabolic syndrome, inflammation, and genetic factors. While observational studies and meta-analyses indicate an inverse relationship between 25OHD levels and diabetes risk, intervention studies yield mixed results. Some meta-analyses show that vitamin D supplementation reduces diabetes risk, especially in non-obese individuals.
Results and discussion The quality of studies was found to be moderate. In the unadjusted analysis, lower baseline 25OHD levels were associated with a higher risk of incident diabetes in older adults. The meta-analysis included 15,924 participants , indicating a significant association. No publication bias was detected , and the trim and fill analysis did not alter these results.
Vitamin D Diagnostic Inflammation Insulin Metabolism Nutrients Type 2 Diabetes Vitamin D Deficiency
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