Some patients with advanced heart failure can benefit from the support of a continuous-flow left ventricular assist device (CF-LVAD) to sustain heart function. However, despite improvements managing complications associated with the use of CF-LVADs, stroke continues to be a major adverse event after the implantation of the device.
Baylor College of Medicine Nov 12 2024 Some patients with advanced heart failure can benefit from the support of a continuous-flow left ventricular assist device to sustain heart function. However, despite improvements managing complications associated with the use of CF-LVADs, stroke continues to be a major adverse event after the implantation of the device.
Previous studies have shown that mitochondria, cellular structures that provide cells with the energy they need to conduct their activities, play a vital role in stroke. Specifically, reduced levels of OxPhos mitochondrial proteins in white blood cells have been associated with disease severity. "Dr. Mondal was looking for students with a background in machine learning. I have knowledge in this area and the project was in cardiothoracic surgery, a field I am interested in," Scioscia said. "It looked like a good opportunity to gain experience in basic science research and meet experts in the field."
The study shows for the first time the existence of mitochondrial dysfunction in white blood cells of patients with congestive heart failure who had a stroke, even before CF-LVAD implantation. "The findings suggest that changes on OxPhos proteins could serve as indicators, predicting new post-CF-LVAD strokes," Scioscia said.
Stroke Blood Heart Heart Failure Medicine Mitochondria Research Students Surgery
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