Rheumatoid arthritis is a common disease affecting an estimated 17 million people worldwide. The disease is caused by immune cells attacking the joints and can result in pain, swelling, and damage to the cartilage and bone.
American Institute of PhysicsNov 5 2024 People with rheumatoid arthritis often develop osteoporosis, a more serious condition, as a result of the bone damage caused by immune cells and as a side effect of certain medications.
Both diseases center on one of the key mechanisms used to keep the rest of the body in check. Apoptosis, or programmed cell death, is a crucial tool immune cells use to remove malfunctioning or unneeded cells. However, malfunctions can lead to immune cells mistakenly targeting cells at random, with often disastrous results.
"We used bioinformatics tools to analyze large gene datasets, focusing on genes active in rheumatoid arthritis and osteoporosis," said Lo. "We applied machine learning techniques, such as Lasso and Random Forest, to refine our search, identifying two key genes -; ATXN2L and MMP14 -; that play significant roles in both diseases."
"Our analysis revealed that these genes are involved in immune regulation and bone metabolism, suggesting they could be useful markers for diagnosing or treating both rheumatoid arthritis and osteoporosis," said Lo.
Genes Osteoporosis Rheumatoid Arthritis Apoptosis Bioengineering Bioinformatics Bone Cartilage Gene Genetic Hospital Machine Learning Pain
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