Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient.
Broad Institute of MIT and HarvardAug 9 2024 Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses , are often slow and inefficient.
The findings, which appeared recently in Nature Communications, come from the lab of Ben Deverman, institute scientist and director of vector engineering at the Stanley Center for Psychiatric Research at the Broad. Fatma-Elzahraa Eid, a senior machine learning scientist in Deverman's group, was the first author of the study.
Group leader Ken Chan, graduate student Albert Chen, research associate Isabelle Tobey, and scientific advisor Alina Chan, all in Deverman's lab, also contributed significantly to the study. Deverman and Eid realized that datasets based on existing large AAV libraries weren't well suited for training machine learning models. "Instead of just taking data and giving it to machine learning scientists we thought, 'What do we need to train machine learning models better?'" Eid said. "Figuring that out was really instrumental."
Gene Therapy Machine Learning Capsid Cell Genes Genetic Liver Protein Research
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Machine learning approach helps researchers design better gene-delivery vehicles for gene therapyGene therapy could potentially cure genetic diseases, but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient.
Read more »
Adeno-associated virus vectors can trigger innate immune pathwaysAdeno-associated virus (AAV)-based viral vectors used in human gene therapy can trigger innate immune pathways, leading to the initiation of adaptive immune responses.
Read more »
Existing drug shows promise for treating common liver diseaseThe University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people.
Read more »
Toyota to race hydrogen car alongside existing hypercar in 2028 WECToyota's hydrogen-powered Le Mans racer built to new rules would not contest every WEC round in 2028
Read more »
Examining existing gaps in food insecurity researchAbout 10% of the United States population experiences some level of food insecurity each year, but little research has been conducted on the key details.
Read more »
Combination therapy incorporating three existing drugs shows potential for treating retinal degenerationsDrug repurposing shows promise in the treatment of retinal degenerations, according to a new study by an international team of researchers, published in Nature Communications.
Read more »