Magnetite Nanoclusters Covered in Carbon Could Boost Cancer Therapy nanomedicine nano carbon
Feb 20 2023Reviewed by Megan Craig, M.Sc. A near-infrared -II-responsive carbon-coated iron oxide nanocluster has been the focus of new research by Professor Hui Wang, Professor Wenchu Lin and Associate Professor Junchao Qian from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, showing promise in enhancing integrated photothermal and chemodynamic therapy for synergistic cancer therapy.
Magnetite nanocrystals have been extensively utilized as Fenton reagents as a result of their biocompatibility and non-invasive imaging ability. However, when magnetite nanocrystals are used as nanozymes, their ferromagnetic behavior and simple oxidization result in colloidal instability and restrict imaging-guided cancer therapy.
The CCMNCs possess superparamagnetic nature and fast magnetic response for separation, enabling them to be used as a contrast agent for T2-weighted MRI. Furthermore, Wang described how the CCMNCs worked. Fe2+ and Fe3+ were discovered in the dissolution of CCMNCs in the tumor microenvironment. Fe2+ produced OH in situ in cells and mice, which in turn helped kill cancer cells and curbed tumor growth via CDT effects. Fe3+ could help decrease intracellular glutathione levels and improve the deleterious effects caused by OH, thus enhancing CDT efficiency.
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