Drop in 21st Century Cures Act funding will slow BRAIN and All of Us projects
All of Us, a massive National Institutes of Health study to develop personalized medicine, will have to curb enrollment of study participants because of a funding shortfall.When the U.S. government’s spending bills for this year were belatedly finalized in March, the U.S. National Institutes of Health largely escaped the major cuts that struck some other several science agencies.
The two programs’ woes stem in part from a 2016 law, the 21st Century Cures Act, which created a 10-year pot of money for them from sources such as oil reserve sales and a public health fund created by the Affordable Care Act. The Cures act specified fluctuating annual funding levels for the two programs, with an unusually large ramp-up in 2023. Each year, NIH has requested additional money to meet each effort’s planned budget, which Congress typically provided.
BRAIN applicants can apply to other NIH programs or the National Science Foundation, whose own budget was slashed 8% for this year. Still, “Some really exciting science is going to be left on the table,” Ngai says, and “desperately needed cures for human brain disorders will be delayed.” On social media, some neuroscientists have called the cutsand urged colleagues to lobby Congress to restore BRAIN’s full funding.
More than 10,000 researchers are already using All of Us data, and they have published hundreds of papers, such as a landmark one in February describing hundreds of. “Pulling back on this vision would be harmful not just to individual projects, but to this country’s decades of leadership in the life sciences worldwide,” says Broad Institute human geneticist Heidi Rehm, who co-leads an All of Us genome sequencing center.
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