Vital research findings pointing to improved treatment for children with Group 3 medulloblastoma brain tumors have been revealed in two major studies published in the journal Neuro-Oncology.
Northumbria University, NewcastleOct 9 2024
Led by Professor Steve Clifford, Director of Newcastle University Centre for Cancer, the INSTINCT research programme set out to identify key genetic defects and find effective targeted approaches to treating Group 3 medulloblastoma. They were able to identify for the first time specific groups of patients who are currently near incurable and urgently require new approaches.
Medulloblastomas with MYC gene amplifications are one of the biggest challenges in pediatric oncology. In our latest studies, we have identified an important group of these tumors which are essentially incurable using current therapies, and how to recognize them diagnostically. Dr. Magretta Adiamah, a developing postdoctoral researcher, led the second part of the study exploring targeted metabolic therapies for MYC medulloblastoma during her PhD studentship at Newcastle University. She said: "Our study opens the possibility of targeting MYC medulloblastoma through a metabolic vulnerability created by MYC itself. It is promising that we can selectively target MYC medulloblastoma by understanding what it takes to grow so aggressively.
"Whilst diagnostics have progressed, surprisingly the actual treatment for medulloblastoma has changed little in 30 years, with the prognosis for high-risk versions remaining stubbornly poor. It is essential that we develop novel approaches to target high-risk disease far more effectively and give kids like Will a chance for the future."
Brain Cancer Cancer Children Charity Drugs Gene Genetic Hospital Medulloblastoma Oncology Research
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