Despite improved survival rates and guideline recommendations, many eligible patients with metastatic Merkel cell carcinoma are not receiving immunotherapy.
. However, findings from a new study suggest that many patients who are eligible for immunotherapy are not receiving this treatment, despite guideline recommendations, and survival outcomes are better at high-volume centers.
MCC is a neuroendocrine skin cancer with a high rate of mortality, and even though it remains relatively rare, its incidence has been rising rapidly since the late 1990s and continues to increase.
Those who received immunotherapy had a 35% decrease in the risk for death per year compared with those who did not. The 1-, 3-, and 5-year survival rates were 47.2%, 21.8%, and 16.5%, respectively, for patients who did not receive immunotherapy, compared with 62.7%, 34.4%, and 23.6%, respectively, for those who were treated with these agents.
From 2017 to 2019, 54.2% of patients with metastatic MCC received immunotherapy. The data also showed an increase in use from 45.1% in 2017 to 63.0% in 2019."This is an effective treatment for aggressive malignancy, so we have to ask why more patients aren't getting them," said Cheraghlou.
Biologics Skin Cancer Malignant Skin Neoplasm Immunotherapy Merkel Cell Carcinoma Merkel Cell Cancer Trabecular Cancer Apudoma Of Skin Small Cell Neuroepithelial Tumor Of The Skin Small Cell Neuroepithelial Tumour Of The Skin MCC Merkel Cell Carcinoma (MCC) MCC - Merkel Cell Carcinoma Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Clinical Guidelines
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