A study published in PNAS provides a comprehensive look at the relationship between cell size and count across the human body, drawing from over 1,500 sources and identifying around 400 unique cell types. The research reveals an almost inverse relationship between cell size and count, offering a quantitative framework that could serve as a baseline for understanding cellular composition and function in various applications.
By Vijay Kumar MalesuSep 19 2023Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal PNAS, researchers examined the relationship between cell size and count across the human body, establishing a quantitative framework and uncovering large-scale cellular patterns.Background Cells, the foundational units of life, maintain specific sizes consistent across mammals, with larger bodies having more cells than larger ones.
The study adjusted cell sizes for myocytes and nerve cells based on system growth or shrinkage, though counts remained consistent across genders and ages. The male model revealed that blood cells weigh about 4.7 kg, divided into 53 types spanning 30 tissue systems. Data from the International Commission on Radiological Protection , including tissue masses and fat and protein contents, was gleaned from autopsies and imaging.
Cell class distributions across select tissues. Cell count and biomass distributions across 18 broad cell classes are shown for the 32 most significant tissue systems of the body, representing about half of all 60 investigated tissue systems, including the vast majority of total cell biomass. Numerical values refer to a reference male except for the female breasts, uterus, and ovaries. Most tissue systems are dominated by the ≈140 distinct cell types making up the epithelial cell class.
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