Harlequins fly-half Smith starts in the number 15 jersey for the first time having appeared as a replacement in the previous four Tests.
Owen Farrell returns from suspension to lead the team at fly-half as Steve Borthwick makes 12 changes in personnel for the clash against the lowest-ranked side in Pool D at Stade Pierre-Mauroy on Saturday.
However, George Ford has not been given the weekend off after being picked on the bench, raising the prospect that three players whose primary position is 10 could be on the field at the same time.
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