Response to The Super Mario Bros Movie's first trailer on YouTube has been overwhelmingly positive, despite the ongoing debate over Chris Pratt's voice.
Pratt’s voice in the film is the main point of contention among Mario fans, who otherwise appear to be happy with what’s been shown so far.for not using Nintendo veteran Charles Martinet as the voice of Nintendo’s mascot in the film.Further readingThe first trailer for the film was released earlier this week
“Voice actors: I’m gonna put my heart and soul in this for at least 20 years, help sell billions in merch, make the studios millions of dollars and make generations around the world happy,” she wrote. “Hollywood: We don’t care.”The Super Mario Bros Movie is due to be released in North America on April 7, 2023. European release dates have yet to be confirmed.
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Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis - BMC MedicineBackground The beneficial role of gut microbiota and bacterial metabolites, including short-chain fatty acids (SCFAs), is well recognized, although the available literature around their role in colorectal cancer (CRC) has been inconsistent. Methods We performed a systematic review and meta-analysis to examine the associations of fecal SCFA concentrations to the incidence and risk of CRC. Data extraction through Medline, Embase, and Web of Science was carried out from database conception to June 29, 2022. Predefined inclusion/exclusion criteria led to the selection of 17 case-control and six cross-sectional studies for quality assessment and analyses. Studies were categorized for CRC risk or incidence, and RevMan 5.4 was used to perform the meta-analyses. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using a random-effects model. Studies lacking quantitation were included in qualitative analyses. Results Combined analysis of acetic, propionic, and butyric acid revealed significantly lower concentrations of these SCFAs in individuals with a high-risk of CRC (SMD=2.02, 95% CI 0.31 to 3.74, P=0.02). Additionally, CRC incidence was higher in individuals with lower levels of SCFAs (SMD=0.45, 95% CI 0.19 to 0.72, P=0.0009), compared to healthy individuals. Qualitative analyses identified 70.4% of studies reporting significantly lower concentrations of fecal acetic, propionic, butyric acid, or total SCFAs in those at higher risk of CRC, while 66.7% reported significantly lower concentrations of fecal acetic and butyric acid in CRC patients compared to healthy controls. Conclusions Overall, lower fecal concentrations of the three major SCFAs are associated with higher risk of CRC and incidence of CRC.
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Harley Quinn voice actor criticises Chris Pratt Mario casting: ‘It should be Charles’ | VGCA prominent voice actor has criticised Nintendo and Illumination for not using legendary Mario voice actor Charles Martinet as the voice of Nintendo’s mascot in the upcoming animated film.
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Tara Strong comments on Chris Pratt's casting in the Super Mario movie: 'it should be Charles'Voice actor Tara Strong has criticised the new Mario movie for not offering the titular role to Mario's in-game voice a…
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Now the Silent Hill movie director claims ‘multiple’ games are in the works | VGCNow the Silent Hill movie director claims ‘multiple’ games are in the works by 'several' teams.
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