Brighton defender Pervis Estupinan will be out for a month with a muscle injury, meaning he misses the historic Europa League trip to Marseille.
"He's an important player we are losing. We have to be good enough to get the result without important players," said boss Roberto de Zerbi.
Albion sit in sixth place in the Premier League, the same position they finished last season - but come into the game on the back of their surprise thrashing by Villa."I know very well the quality of people inside my dressing room. I think we will react in the best way - the attitude, the passion we show from here to the end of the season will be totally different.
"We have to change many players game by game. The defeat against West Ham or at Villa Park is not because I changed a lot of players. I believe in my players and squad.'Remember that you are actually in control':
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