Mass screening for atrial fibrillation with ECG and biomarker fails to prevent stroke in older adults

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Mass screening for atrial fibrillation with ECG and biomarker fails to prevent stroke in older adults
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Mass screening for atrial fibrillation using ECG together with heart failure biomarker does not prevent ischaemic stroke or systemic embolism (blood clot) in older adults aged 75-76 years over 5 years follow-up, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug - 2 Sept).

European Society of Cardiology Sep 2 2024 Mass screening for atrial fibrillation using ECG together with heart failure biomarker does not prevent ischaemic stroke or systemic embolism in older adults aged 75-76 years over 5 years follow-up, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK .

People with AF are five times more likely to have a stroke, and the stroke is more likely to be debilitating with a lower chance of surviving, but around 30% have no AF symptoms, underscoring the urgent need to identify people with this potentially dangerous heart rhythm. In 2020, the baseline screening results of the STROKESTOP II trial showed that NTproBNP can be useful as a stratifying tool for screening of AF, and that those with elevated NTproBNP might benefit from more intensive screening.

Participants without previously known AF had blood samples taken and NT­proBNP levels analysed and were then stratified into high risk and low risk groups. They were then screened, based on NT-proBNP level, to either one time or more intensely . After a median follow-up of 5 years, no difference was noted in the risk of any stroke or clotting event between the intervention group and the control group.

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