Mass spectrometry and glycobiology - what are the genetic applications?

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Mass spectrometry and glycobiology - what are the genetic applications?
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In this new episode of the omg OMx podcast, Kate Stumpo speaks to Chris Taron about his experience in glycobiology, the use of mass spectrometry in that field, and the implications for genetic research.

Sponsored Content by Bruker Life Sciences Mass SpectrometryMar 7 2024Reviewed by Louis Castel Thought LeadersChris TaronSenior Scientific DirectorGloucester Marine Genomics Institute In this new episode of the omg OMx podcast, Kate Stumpo speaks to Chris Taron about his glycobiology experience, mass spectrometry use in the field, and the implications for genetic research.

We also had the freedom to chase our ideas, which is a significant reason why I stayed with one organization my whole career. I was privately funded to pursue my ideas. It is truly special when you are not burdened with fundraising and grant writing and can instead focus on cutting-edge research, collaborate with academics, publish, and more. This is why many people from NEB have remained as career-long researchers there.

When working with enzymes like that, you often use various analytical techniques. So, my journey through glycobiology has been closely tied to the analytical aspects of the field. I would put it in the 1990s timeframe. Back then, people were primarily characterizing individual glycoproteins, and they used various types of mass spec depending on the lab doing the work. Different labs had different flavors. I think there has been some convergence over time regarding the types of analyses performed in mass spectrometry.

We tiptoed into it. I do not want to say that we were experts in this. We took it slowly through collaborations with people like Pauline Rudd and the National Institute of Bioprocess Research and Training in Dublin, Ireland. Over time, we began to do more of it independently, but we had a lot of help along the way.

If you go to a space like the ocean and start looking at microbes that have not been discovered yet, from ecological niches that are poorly understood, you start to wonder: What is the genetic makeup? What is the role of proteins in these environments? The potential for discovery is truly enormous.

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