Maternal medications linked to changes in protein and fat levels in human milk

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Maternal medications linked to changes in protein and fat levels in human milk
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The impact of maternal antidepressant and anti-inflammatory use on breast milk composition shows reduced protein and fat levels, affecting infant nutrition.

By Vijay Kumar MalesuReviewed by Danielle Ellis, B.Sc.Jan 9 2025 Breast milk from mothers on antidepressants or anti-inflammatory drugs shows reduced protein and fat levels

Over 70% of breastfeeding mothers use medications, yet their impact on milk composition remains unclear. Further research is needed to understand how medications may influence macronutrient levels in human milk. Medicated mothers were categorized into four groups based on exposure: selective serotonin reuptake inhibitors , monoclonal antibodies , systemic corticosteroids, and other anti-inflammatory drugs . Samples from mothers exposed to multiple medications were excluded.

Study results The study analyzed 384 milk samples, including 63 exposed to SSRIs, 63 to MABs, 33 to systemic steroids, 20 to other ADs, 141 from DMCs, and 64 from healthy, unmedicated mothers. Among the mothers, 7.0% were Asian, 12.5% non-Hispanic Black, 12.5% Hispanic, 75.8% non-Hispanic White, and 2.9% from other racial or ethnic groups.

Mood disorder prevalence was lower in SSRI-treated mothers compared to DMCs , while inflammatory disorder prevalence was lower among AD-treated groups compared to DMCs.

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