Mayo Clinic researchers uncover microbial signatures linked to gynecologic cancers

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Mayo Clinic researchers uncover microbial signatures linked to gynecologic cancers
Ovarian CancerBacteriaDiabetes
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Early detection improves treatment outcomes for endometrial and ovarian cancers, yet far too often women are diagnosed in advanced stages of these diseases.

May 30 2024Mayo Clinic Unlike many other cancers, there are no standard screenings for early detection of endometrial and ovarian cancer s. The incidence rate for endometrial cancer is expected to rise, driven by environmental factors, obesity and diabetes.

"Screening the microbiome for early detection may improve patient outcomes," says Dr. Walther-Antonio, also a researcher at the Departments of Surgery and Obstetrics and Gynecology, and the Mayo Clinic Comprehensive Cancer Center. In their research on ovarian cancer, the team found a distribution of microbes in the reproductive tract of women with the disease. They also revealed changes in the microbiome compositions that are correlated with patient treatment outcomes. These findings may open investigation avenues into applicability of these markers to detecting and predicting treatment response.

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