Methods to rapidly determine ligand target engagement are valuable tools in drug discovery. Developinga straightforward platebased assay workflow allows compatibility with HTS settings.
Sponsored Content by ELRIG Ltd.Reviewed by Laura ThomsonJul 15 2024 This poster was originally authored by John Vincent, Matthew Burnham, Gerrit Daubner, and Martin Main of the Medicines Discovery Catapult. It was presented at ELRIG Drug Discovery 2023.
The Chemical Protein Stability Assay is a simplified single well, plate‐based workflow without plate transfer, suited to compound screening and hit finding, and compatible with multiple assay endpoints. The patent-pending technology does not require labeling a tracer ligand or modifying the target protein.
Conclusions MDC has developed a proprietary chemical protein stability assay that is comprised of a simple, cost‐effective workflow without transfer steps and applies to compound profiling and hit identification. The patent pending assay applies to a range of protein targets and can be configured using a range of protein detection technologies. The CPSA can generate high‐quality data in both dose-response and single-point format to detect the engagement of compounds with target proteins.
(CPSA) Novel Target Engagement Approach
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