MDMA could soon be a medicine - it would be groundbreaking for those with depression ✒️ ProfDavidNutt via ipaperviews
But trauma doesn’t always lead to PTSD – in fact half of all the people who develop a mental health issue as a result of trauma become depressed. We don’t know why this is, though perhaps prior low mood predisposes to this outcome, as stress is a major factor in all forms of depression.
What we do know is that MDMA treatment for PTSD and also alcohol dependence improves mood – so it is plausible that it might work in people who are just depressed. In fact, in my clinical practice, as a specialist in the treatment of depression, I heard from a number of patients whose depression responded to MDMA when it hadn’t to conventional antidepressants.
Of course, because of the illegal status of MDMA I couldn’t recommend this approach, but I think it supports the rationale for developing a proper study. This will not be easy given the current position of MDMA as a Schedule 1 controlled drug, which adds a great deal of extra time and costs for research.
Just a couple of weeks ago there was a back-bench debate on the need to re-schedule MDMA and psilocybin, a psychedelic drug that has also shown efficacy in mental illnesses. There was cross-party agreement that such a change was urgently needed and a representative of the Home Office agreed to explore this. As about 450 people in the UK die by
each month, and the majority will either have depression or addiction, it is essential that they do so quickly.
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