mRNA vaccines saved lives during the COVID-19 pandemic, but older people had less of an immune response to the vaccines than did younger adults. Why? Boston Children's researchers, led by Byron Brook, PhD, and Ofer Levy, MD, PhD, have found some answers, while providing proof-of-concept of a new system that can model vaccine responses in a dish.
Boston Children 's Hospital Nov 15 2024 mRNA vaccines saved lives during the COVID-19 pandemic, but older people had less of an immune response to the vaccines than did younger adults. Why? Boston Children 's researchers, led by Byron Brook, PhD, and Ofer Levy, MD, PhD, have found some answers, while providing proof-of-concept of a new system that can model vaccine responses in a dish.
Multi-pronged monitoring The team collected blood samples from people in different age groups and added the Pfizer/BioNTech COVID mRNA vaccine to the samples. Extensive tests, including proteomics and systems biology approaches, then measured immune activation in response to the vaccine. While mouse studies have traditionally been considered a gold standard for research, they are expensive, time-consuming, and don't always accurately capture human immune biology. In 2022, Congress passed the FDA Modernization Act 2.0, which allows for alternatives to animal testing, including human cell and organoid models alongside systems biology approaches.
Blood Children Covid-19 Cytokines Hospital Immune Response Immunity Pandemic Proteomics Research Technology Vaccine
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