Comprehensive study within a large Swedish cohort links elevated glucose and triglyceride levels to an increased risk of developing depression, anxiety, and stress-related disorders, while higher HDL-C levels seem protective, suggesting a significant connection between metabolic health and psychiatric conditions.
By Vijay Kumar MalesuApr 3 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the JAMA Network Open, a group of researchers determined if carbohydrate, lipid, and apolipoprotein biomarkers are linked to the future development of depression, anxiety, and stress-related disorders in a large Swedish cohort.
About the study The Swedish Apolipoprotein-Related Mortality Risk cohort, spanning from 1985 to 1996 and predominantly in the Stockholm region, includes 812,073 participants who underwent routine health screenings or were referred for laboratory testing due to health conditions. For this study, 211,200 participants over 16, free from mental disorders at baseline and with at least one biomarker measurement, were selected.
Study results In the substantial cohort of 211,200 participants, consisting of 58% males and 42% females, with the vast majority born in Sweden , the study observed notable trends over a mean follow-up period of 21 years. The participants had an average age of 42.1 years at their first blood sampling, with diagnoses of depression, anxiety, or stress-related disorders emerging at a mean age of 60.5 years.
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