Science, Space and Technology News 2024
Researchers have found that the molecule lac-phe, produced after intense exercise, is responsible for weight loss seen in metformin users, linking it to appetite control and metabolism. Studies show that metformin increases lac-phe levels, mirroring the effects of vigorous exercise, suggesting new pathways for developing weight loss drugs.
The finding, made jointly by researchers at Stanford Medicine and at Harvard Medical School, further cements the critical role the molecule, called lac-phe, plays in metabolism, exercise and appetite. It may pave the way to a new class of weight loss drugs. “There is an intimate connection between lac-phe production and lactate generation,” Long said. “Once we understood this relationship, we started to think about other aspects of lactate metabolism.”Metformin was an obvious candidate because as it stimulates the breakdown of glucose it can trigger the generation of lactate.
Finally, a statistical analysis of the people in the atherosclerosis study who lost weight during the several-year study and follow-up period found a meaningful association between metformin use, lac-phe production, and weight loss.
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