People with opioid use disorder in British Columbia who received methadone had a 37–40 per cent lower rate of treatment discontinuation compared with those who received buprenorphine/naloxone.
Simon Fraser UniversityOct 21 2024
Reducing the risk of treatment discontinuation saves lives. With thousands of lives lost since the introduction of fentanyl into B.C.'s unregulated drug supply, it is important that we continue to evaluate the best available treatment options. Comparative studies like this using high-quality health administrative data are one of the best sources of evidence we have to evaluate how our treatment options are performing as the toxic drug supply continues to evolve.
The study, Buprenorphine/naloxone versus methadone for the treatment of opioid use disorder, was a collaboration between scientists and public health professionals from the Centre for Advancing Health Outcomes, Simon Fraser University, BC Centre on Substance Use, University of British Columbia , and McGill University in Canada, and universities and institutions in the United Kingdom, Austria, and across the United States.
The study found that the risk of treatment discontinuation was lower among recipients of methadone compared with buprenorphine/naloxone. The risk of mortality was low during treatment and did not differ meaningfully between the two medications . Importantly, these findings were consistent after the introduction of fentanyl and across patient subgroups, including youth , people with severe mental disorders, and people with concurrent chronic pain.
Mortality Addiction Agonist Education Fentanyl Health Care Medicine Overdose Public Health Research
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