In 1817, a British physician named James Parkinson published An Essay on the Shaking Palsy, describing for the first time cases of a neurodegenerative disorder now known as Parkinson's disease. Today, Parkinson's disease is the second most common neurodegenerative disease in the U.S.
Mitochondria keep your brain cells alive: Helping them run smoothly may protect against Parkinson's disease, describing for the first time cases of a neurodegenerative disorder now known as Parkinson's disease. Today, Parkinson's disease is theidentified a key proteinUnlike actual power plants, which are set in size and location, mitochondria are rather dynamic.
We also observed behavior changes in rats that impaired their movements. By reducing the activity of Drp1, however, we were able tothan to its mitochondria, causing buildup of toxic proteins before mitochondria became dysfunctional. Inhibiting Drp1, however, coaxed the waste recycling system back into action, cleaning up toxic proteins despite the presence of manganese.
Our findings indicate that inhibiting Drp1 from more than one pathway could protect cells from degeneration. Now, we've identified some FDA-approved compounds that target Drp1 and are testing them as potential treatments for Parkinson's.: Mitochondria keep your brain cells alive: Helping them run smoothly may protect against Parkinson's disease retrieved 31 August 2024 from https://medicalxpress.com/news/2024-08-mitochondria-brain-cells-alive-smoothly.
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