Moderna's updated mRNA-1273.815 COVID-19 vaccine shows promising results in reducing symptomatic cases, hospitalizations, and deaths in high-risk and older adults in Germany. The study finds the vaccine to be more cost-effective and clinically beneficial than both no vaccination and Pfizer's XBB.1.5 BNT162b2 vaccine.
By Tarun Sai LomteOct 12 2023Reviewed by Susha Cheriyedath, M.Sc. In a recent study posted to medRxiv preprint* server, researchers at pharmaceutical and biotechnology company Moderna, Inc. estimated the economic and clinical impact of updated messenger ribonucleic acid vaccines for coronavirus disease 2019 .
The global health emergency of COVID-19 ended in May 2023, after 12 months of declining incidence of severe acute respiratory syndrome coronavirus 2 infections. The Omicron variants and high population immunity due to infection and vaccination have resulted in significantly fewer cases of severe disease than at the start of the pandemic. The epidemiologic situation in Germany has shifted from a pandemic to endemic SARS-CoV-2 circulation.
About the study In the present study, researchers modeled the clinical and economic impact of the mRNA-1273.815 vaccination in high-risk individuals aged 30-59 and older adults in Germany. A previous susceptible-exposed-infectious-recovered model was adapted to examine the impact of mRNA-1273.8.15 vaccination.
It was assumed that additional primary series/first booster and second/third booster doses were not administered after February 27 and December 21, 2022, respectively. Coverage and uptake of both updated mRNA vaccines were assumed to be the same as for influenza vaccine season during 2021-22 in Germany.
Findings mRNA-1273.815 vaccination was associated with better clinical outcomes and lower costs than no vaccination. The model predicted 12.9 million symptomatic cases, 305,711 hospitalizations, and 11,125 deaths without vaccination between September 2023 and August 2024. However, mRNA-1273.815 vaccination would have reduced symptomatic cases, hospitalizations, and deaths by 13.1%, 27.9%, and 36.8%, respectively, relative to no vaccination.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Manchester Half Marathon 2023 route, road closures and everything to knowAll the essential information you need on the 13.1 mile route through the city taking place on Sunday 15 October
Read more »
Wigan back French named 2023 Man of SteelWigan Warriors back Bevan French wins the 2023 Steve Prescott MBE Man of Steel award for the best player in Super League.
Read more »
Newcastle United players – All 20 rated for 2023/24 season so far via independent rankingsAll 20 Newcastle United players rated for 2023/24 season so far via independent rankings
Read more »
Marquez: ‘Objective is to finish 2023 in the best way’ at HondaMarc Marquez says his intention for the remainder of the 2023 MotoGP campaign is to ‘do our maximum to finish in the best way possible’.
Read more »
Telford entrepreneur bags award nominations with new business set to make £1.5m in 2023Business Editor covering Shropshire and Mid Wales. Got a story? Get in touch at matthew.pantermnamedia.co.uk.
Read more »
Amazon Prime Day October 2023: When does Amazon Prime day endShoppers haven't got long to snap up any final deals
Read more »