Withanolides, a class of naturally occurring compounds found in plants, have long been a focus of cancer research due to their ability to inhibit cancer cell growth, induce cell death and prevent metastasis.
H. Lee Moffitt Cancer Center & Research InstituteJun 28 2024 These compounds are important in developing new cancer treatments. However, the difficulty of obtaining enough of these compounds from plants has hindered research and therapeutic development.
Our new synthesis route represents a major step forward in the field of withanolide chemistry. By enabling the diversifiable production of these compounds on a gram scale, we can now support more extensive biological research and medicinal chemistry efforts." Key aspects of the new synthesis include a bioinspired photooxygenation-allylic hydroperoxide rearrangement sequence, which facilitates the introduction of functional groups at the late stages of the synthesis. This approach ensures scalability and allows for the concise preparation of numerous different withanolides from the same synthesis. It also removes the dependency on plant extraction, which is time consuming and limited by the natural abundance of these compounds.
Related StoriesAnother critical aspect is their ability to overcome drug resistance. Cancer cells can develop resistance to conventional treatments over time, but withanolides, due to their unique mechanisms of action, may help overcome this resistance and remain effective where other treatments fail.
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Researchers develop scalable synthesis of cancer-fighting compoundsWithanolides, a class of naturally occurring compounds found in plants, have long been a focus of cancer research due to their ability to inhibit cancer cell growth, induce cell death and prevent metastasis. These compounds are important in developing new cancer treatments.
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