Researchers have built the first-ever molecular atlas of the human brain vasculature at single-cell resolution, spanning from early development to adulthood and through disease stages such as brain tumors and brain vascular malformations.
Molecular atlas of blood vessel pathways in the human brain, across early brain development, adulthood and disease
In this study, researchers isolated blood vessels from human early developing brains, adult brains, brain tumours and brain vascular malformations. They found that endothelial cells, which line the blood vessels and regulate interactions between the bloodstream and surrounding tissues, behave differently across various stages of brain development, and may have a more important role than previously understood within the brain's neurovascular signaling networks.
The research team also showed for the first time how the human brain vasculature differs from the vasculature of organs outside the brain, both during early brain development and in adulthood -- and when disease arises, the brain vasculature becomes more like that of a peripheral organ. "Both the early developing brain, and brain tumours and brain vascular malformations, feature blood vessel growth and immunosuppression which allow for undisturbed tissue growth. If we can dampen or inhibit the growth of the blood vessels and at the same time boost the immune system, that has a potential application to therapy."
This research aims to build on the momentum in the field of brain vascular biology, over the past several years.
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