Uncover the role of the LAG-3 protein in cancer development and immune evasion. Promising breakthroughs in cancer treatment.
Protien called LAG-3 which is known to prevent cancer detection was observed at the atomic level shows promise for new cancer treatments.Now, researchers from Stanford University and New York University have found a detailed structure of a protein–LAG-3- often exploited by cancerous tumors to
Jennifer Cochran, the Addie and Al Macovski Professor in the School of Engineering professor of bioengineering, and co-senior author on the study detailing LAG-3 stated: According to Jack Silberstein, the Stanford immunology Ph.D. student who co-led the work noted that LAG-3 seems to work in an entirely different way compared to other proteins; finding the differences could help evolve treatments.
“I quickly realized why there was no published structure. It’s a tremendously difficult protein to work with,” added Silberstein., Silberstein first had to grow a crystal made entirely from LAG-3 protein. Then, in collaboration with Irimpan Mathews at the SLAC National Accelerator Laboratory, they fired X-ray beams at the crystal to create a 3D image of the molecule.
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