Researchers investigated the impact of aldosterone infection in db/db mice on HFpEF, focusing on sex differences and alterations in intracellular calcium handling and cardiomyocyte electrophysiology.
By Pooja Toshniwal PahariaJun 4 2024Reviewed by Danielle Ellis, B.Sc. Sex differences in cardiovascular illnesses are becoming more well-acknowledged, although women are under-represented in clinical studies. Pre-menopausal women have a decreased risk of coronary artery diseases with lower vulnerability to ischemic heart damage and heart failure due to a lower ejection fraction, which reduces postmenopausal complications.
The team block-randomized the animals using a block size of four with 24 controls , 24 aldosterone-infused db/db mice, and eight aldosterone-infused wild-type mice, and eight saline-infused mice for one-hit controls. They euthanized the animals to isolate their cardiomyocytes. Results Female HFpEF murine animals showed lower BNP expression than males, with equivalent comorbidities and heart hypertrophy. Male HFpEF murine animals showed greater cardiac alternans susceptibility. Male HFpEF cardiomyocyte cells had greater diastolic calcium ions, slower calcium transient decaying, a lower L-type calcium current, more dramatic amplification of late sodium currents, and higher short-term APD variability.
Heart Failure Aldosterone Arrhythmia Blood Calcium Diabetes Diastolic Dysfunction Electrophysiology Frequency Glucose Intracellular Kinase Potassium Protein Research Translation
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