Defining the News
Paris, France—As fears mount globally about mpox, apparently simple questions such as the danger it poses and differences between variants do not have clear and simple answers.
That uncertainty grew from 2022, when mpox spread elsewhere in the world, especially to Western countries.Such differences likely stem from several variables. The mortality rate measured in the current outbreak—around 3.6 percent—would therefore likely be much lower were it not mostly limited to the DRC.Other factors weighing on the mortality rate include those that make some patients more vulnerable than others.
A further factor adding complexity is the clade, or family, to which the specific virus causing an mpox outbreak belongs. But a distinct second epidemic hitting mostly adults in the same country is linked to variant 1b, a derivative of Clade 1 that has only appeared recently.
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