Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1.
Monash UniversityNov 27 2024 MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear.
Our findings suggest that Vitamin B6 molecules displayed by MR1 represent a means for the immune system to detect altered cellular metabolism/metabolite levels, that may distinguish cancer cells. Dr. Patricia T. Illing, Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University
While it's not yet clear if the Vitamin B6 molecule can be utilised in therapeutics, "understanding the breadth of MR1 mediated immunity has the capacity to illuminate routes for therapeutic intervention," Dr. Illing said.
Immune System Biomedicine Immunity Metabolite Metabolites Molecule Small Molecules
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Ozempic effective for patients with chronic kidney damageIn a 24-week trial, semaglutide led to a 52% reduction in albuminuria and improved kidney health in individuals with chronic kidney disease and obesity.
Read more »
EBUS-TBNA proves effective for tumor molecular analysis in lung cancerTumor molecular analysis using next-generation sequencing (NGS) is the standard of care for guiding lung cancer treatment. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique used to sample mediastinal lymph nodes for diagnosing and staging lung cancer.
Read more »
Early intervention with TAVR proves safe and effective for asymptomatic aortic stenosisThe first powered randomized trial examining early intervention with transcatheter aortic valve replacement (TAVR) in patients with asymptomatic, severe aortic stenosis (AS) found this strategy to be both a safe and effective alternative to clinical surveillance (CS).
Read more »
'Simple but effective' way to keep your pets calm on Bonfire NightDog owners everywhere will be a bit worried ahead of Bonfire Night
Read more »
Budget 2024 LIVE as Rachel Reeves challenges SNP to deliver 'effective' public services after cash boostThe Labour Chancellor has tore into the previous Tory government for overseeing a decade of low growth and austerity.
Read more »
Study reveals effective combination therapy to slow cognitive decline in older adultsAn important new study led by the Centre for Addiction and Mental Health (CAMH), and with partnership across several Toronto Dementia Research Alliance (TDRA) sites-; Baycrest, Sunnybrook Health Science Centre, Unity Health Toronto, and University Health Network-; has demonstrated that a combination therapy can slow cognitive decline in older...
Read more »