MSK researchers identify a new, rare type of small cell lung cancer

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MSK researchers identify a new, rare type of small cell lung cancer
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A team of doctors and researchers at Memorial Sloan Kettering Cancer Center (MSK) have identified a new, rare type of small cell lung cancer that primarily affects younger people who have never smoked.

Memorial Sloan Kettering Cancer CenterSep 11 2024 A team of doctors and researchers at Memorial Sloan Kettering Cancer Center have identified a new, rare type of small cell lung cancer that primarily affects younger people who have never smoked.

"Understanding this new type of lung cancer required a broad spectrum of expertise from the laboratory to the clinic," says Charles Rudin, MD, PhD, a lung cancer specialist and the study's senior author. "Patients who develop small cell lung cancer tend to be older and have a significant history of smoking," says Dr. Rudin, the Deputy Director of MSK's Cancer Center. "The first patient we identified with atypical SCLC, and whose case led us to look for more, was just 19 years old and not a smoker."

That's why patients with atypical SCLC may benefit, for example, from investigational drugs that target the unusual DNA structures that result from chromothripsis, known as extrachromosomal circular DNA, the researchers note. Family and friends show their love Khaliq's family lived in Georgia, but his academic excellence led to his acceptance into a program in Connecticut called A Better Chance of Westport, which provides young scholars of color an opportunity to attend one of the nation's top-performing high schools. In Westport, he lived with Lori and Dave Sochol, who became a second family to him. When things got tough, the Sochols were right there with him.

As Khaliq's disease progressed, his family and friends never left his side. His parents, Angela and Oumarou Sanda, and his brother, Kimbo Sanda, temporarily relocated to spend Khaliq's final months with him. Then, as the end came, dozens of his friends filled the waiting room at the hospital -; some canceling vacations to come pay their respects.'An amazing gift to society and science' Khaliq lived for five years after his diagnosis, which is itself unusual -; the five-year survival rate for patients with advanced SCLC is miniscule.

Dr. Rekhtman and Dr. Rudin praised Khaliq's decision to donate tissue after he died so that his cancer could be further analyzed to help future patients.Angela Sanda agrees, saying, "The doctors did everything they could for him. He received the best care. And I'm glad that they are learning things from his cancer that could help others."

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