Children and adolescents who have had multisystem inflammatory syndrome in children (MIS-C) after exposure to COVID-19 are recommended to have follow-up heart function testing. A new study from Boston Children's Hospital suggests they should also be monitored for long-term neurologic and psychosocial complications.
Dr. Rollins notes that many of these symptoms could be chalked up to stress, including the stress of the COVID-19 pandemic and the way it upended children's school and routines. Because the study included a comparison group that did not have MIS-C—but faced many of the same stressors—she believes the symptoms are likely MIS-C-related.
"When families learn the child's symptoms could be related to MIS-C, they are reassured that others are experiencing it," she says."We hope this study will increase awareness."Rollins is currently following the children with MIS-C for a second year and hopes to add MRI studies of the brain to see if MIS-C caused any structural changes.
In future studies, she hopes to explore how MIS-C predisposes children to neurobehavioral complications and what these children might have in common with adults who report brain fog after COVID-19. As a committee member on the large, she has reviewed data from children who have had COVID-19 or MIS-C as well as adults with long COVID.
"These conditions are very intertwined," says Rollins."The acute illness is very different—children with MIS-C are very sick and often need ICU care, while adults may have mild acute cases of COVID-19 but have lingering brain fog. Both could be part of the same spectrum and the same mechanisms could be underneath."Caitlin K.
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