A recent prospective cross-sectional study in Thailand demonstrates that multitarget stool DNA testing is highly sensitive and specific for detecting colorectal cancer (CRC) among Thai individuals.
BGI Genomics Nov 6 2024 A recent prospective cross-sectional study in Thailand demonstrates that multitarget stool DNA testing is highly sensitive and specific for detecting colorectal cancer among Thai individuals. Research ers believe that this testing method could serve as a viable non-invasive alternative to colonoscopy, especially in settings where colonoscopy is less accessible or less accepted by patients.
Researchers focused on evaluating the diagnostic performance of the multitarget stool DNA testing for detecting CRC and advanced adenoma, using colonoscopy as the reference standard. The study included both asymptomatic and symptomatic patients who underwent stool DNA testing followed by colonoscopy. The multitarget stool DNA test targeted methylation statuses of SDC2, ADHFE1, and PPP2R5C genes. Sensitivity, specificity, and other diagnostic parameters were analyzed.
For advanced colorectal neoplasms, which include both CRC and advanced adenomas, the test demonstrated a sensitivity of 75% and a specificity of 91.9%, marking it as a promising tool for the early detection of serious colorectal conditions. These findings highlight the test's potential as an effective screening option for detecting CRC, especially for larger lesions, although some limitations remain for detecting smaller-sized abnormalities.
Related StoriesThe study results indicate that multitarget stool DNA testing is highly sensitive and specific for CRC detection among Thai individuals. This testing could provide a viable non-invasive alternative to colonoscopy, especially in settings where colonoscopy is less accessible or less accepted by patients.
Colorectal Colorectal Cancer DNA Research Cancer Prevention Colonoscopy Diagnostic DNA Methylation Genes Genomics Hospital Medicine Ph Technology
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