Nanocarriers Inhibit Metastasis in Breast Cancer Mouse Model AdvSciNews breastcancer nanocarrier nanomedicine nanobiotechnology nanotechnology cancer tumor nanoparticles
By Bhavna KavetiOct 17 2022Reviewed by Susha Cheriyedath, M.Sc. Despite the efficiency of chemotherapy in treating primary tumors, it may induce undesirable metastasis because of proinflammatory factors being released from impaired cells, upregulating inflammatory reactions.
Compared to treatment with pure paclitaxel , PXT-loaded nanoparticles showed reduced levels of inflammatory cytokines and cfNAs in the blood serum of a mouse model with breast cancer metastasis, inhibiting primary tumor growth and metastasis. Moreover, the drug-loaded nanoparticles did not show any significant side effects in the serum or other organs, confirming their biosafety.
Chemotherapeutics, including doxorubicin and PTX, are frequently used in combinational therapy against primary breast cancer. Besides their efficiency in treating primary tumors, they promote metastasis by elevating proinflammatory cfNAs that are released into the tumor microenvironment by damaged cells. Addressing the chemotherapy-induced prometastatic effects in breast cancer is therefore necessary.
PTX-Loaded Cationic Nanoparticles Towards Breast Cancer Metastasis Previous studies have described the toxic effects of PAMAM. Although PAMAM-G3 polymers have been used to scavenge cfNAs, the hydrophilic nature of PAMAM-G3 restricts its application in chemotherapeutics, necessitating further modifications.
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