The delivery of nanomedicines using gas bubbles has shown itself to be a unique way of transporting cytotoxins to the lungs of cancer patients.
SINTEFNov 22 2024 The method enables precise and focused treatments, and the local action of the drugs also prevents a range of side-effects.
The study has recently been published in the European Journal of Pharmaceutical Sciences, and the method is so promising that the research team has taken out a patent. SINTEF has also signed a licence agreement with a pharmaceutical company.Andreas Åslund, researcher and Project ManagerFrom a drawback to a benefit It was in many ways something of a coincidence that this technology should end up as a lung cancer medication.
In other words, methods other than delivering drugs via the bloodstream are required in order to reach brain tumors. The researchers have addressed this problem by manufacturing gas bubbles that enclose the nanocapsules containing the drugs. The bubbles make it possible to use ultrasound to explode the nanocapsules, enabling the drugs to be 'shot' through the blood-brain barrier.
"After a while we discovered that these gas bubbles ended up in the patients' lungs", explains Åslund. "In the first instance, an accumulation of gas bubbles here wasn't what we wanted, but the discovery meant that we could turn the problem upside down and instead exploit the phenomenon to reach tumors in the lungs", he says.
Lung Cancer Blood Brain Cystic Fibrosis Drug Delivery Drugs Emphysema Fibrosis Lungs Microbubbles Nanoparticles Research Technology Ultrasound
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