A future treatment for Alzheimer disease may involve a nasal spray. Researchers at Università Cattolica and Fondazione Policlinico Universitario A. Gemelli IRCCS have discovered that by inhibiting the brain enzyme S-acyltransferase (zDHHC) through a nasal-spray drug, they can counteract the cognitive decline and brain damage typical of the disease.
Universita Cattolica del Sacro CuoreNov 26 2024 A future treatment for Alzheimer disease may involve a nasal spray. Research ers at Università Cattolica and Fondazione Policlinico Universitario A. Gemelli IRCCS have discovered that by inhibiting the brain enzyme S-acyltransferase through a nasal-spray drug, they can counteract the cognitive decline and brain damage typical of the disease.
Background The development of Alzheimer is driven by alterations in certain proteins, including beta-amyloid and tau, which aggregate and accumulate in the brain. These proteins' functions are regulated by multiple signals and modifications, including the attachment of a fatty acid molecule in a biochemical reaction called "S-palmitoylation" , which is performed by S-acyltransferase enzymes .
In this new study, we showed that in the early stages of Alzheimer, molecular changes resembling a scenario of brain insulin resistance cause an increase of zDHHC7 enzyme levels and alter the S-palmitoylation of key proteins involved in cognitive functions and beta-amyloid accumulation.
Alzheimer's Disease Brain Diabetes Drugs Enzyme Genetic Insulin Insulin Resistance Nasal Spray Neuroscience Protein Research
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