A groundbreaking nasal swab test developed by University of Pittsburgh researchers promises to revolutionize asthma diagnosis in children. This non-invasive test accurately identifies specific asthma subtypes (endotypes), enabling clinicians to prescribe more targeted medications and paving the way for research into better treatments for lesser-studied asthma types.
Researchers at the University of Pittsburgh have developed a nasal swab test for kids that diagnoses specific asthma subtype, or endotype. This non-invasive approach could help clinicians prescribe medications more precisely and pave the way for research toward better treatments for lesser-studied asthma types, which have been difficult to diagnose accurately until now. Published today in JAMA, the findings are based on data from three independent U.S.
-based studies that focused on Puerto Rican and African American youths, who have higher rates of asthma and are more likely to die from the disease than their non-Hispanic white counterparts. Asthma is the most common chronic disease of childhood, and it disproportionately affects Black and Puerto Rican children, so it's essential that we develop new therapies to better treat these young patients. Because asthma is a highly variable disease with different endotypes, which are driven by different immune cells and respond differently to treatments, the first step toward better therapies is accurate diagnosis of endotype. Juan Celedón, M.D., Dr.P.H., senior author, professor of pediatrics at Pitt and chief of pulmonary medicine at UPMC Children's Hospital of Pittsburgh Traditionally, asthma has been classified into endotypes known as T2-high or T2-low based on the amount of T helper 2 inflammation present. More recently, T2-low has been split into two endotypes: T17-high, which has less T helper 2 inflammation and more T helper 17 inflammation, and low-low, which has low levels of both types of inflammation. Precise diagnosis of endotype usually involves genetic analysis of a lung tissue sample taken by a procedure called a bronchoscopy, which is done under general anesthesi
Asthma Diagnosis Endotype Children Pulmonary Medicine
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